Heathrow’s new Terminal 2 will become the home of the Star Alliance, Aer Lingus and Virgin Atlantic’s domestic routes when it opens in 2014.
The airport said the decision follows a nine-month consultation with airlines, prompted by the sale of bmi to IAG, the parent of British Airways.
The relocations allow the airport to close Terminal 1 early.
Heathrow is still in discussion with other airlines which currently operate from Terminal 1 and who are not members of the Star Alliance.
These are El Al, Icelandair, Cyprus Airways, Germanwings and Transaero.
"We expect to conclude these discussions in early 2013," said a spokesman.
From summer 2013, Virgin Atlantic will operate domestic routes from Heathrow to Manchester, Edinburgh and Aberdeen following the award of ‘remedy slots’ as a result of IAG’s acquisition of bmi.
These flights will initially operate from Terminal 1, where bmi was based, before moving to Terminal 2 in 2014.
Virgin Atlantic’s international flights will continue to operate from Terminal 3. If a tie-up with Delta is approved, the US airline will join Virgin at Terminal 3.
Heathrow said it would continue to work with Virgin on how its services might be co-located in the future.
The new terminal marks the latest phase of an £11 billion transformation of Heathrow.
The £2.5billion Terminal 2 development is the largest privately-funded construction project in the UK.
