American Cruise Lines’ mightiest season on the Mississippi

American Cruise Lines has announced its most comprehensive Mississippi river season for 2025.

There will be five riverboats sailing 12+ itineraries on the river and its tributaries year-round.

The company’s Mississippi river cruise options range from eight to 51 days spanning 10 states from New Orleans, Louisiana to St. Paul, Minnesota.

American Cruise Lines’ Mississippi season officially opens on 21 February aboard American Serenade sailing American’s classic nine-day Lower Mississippi River Cruise from New Orleans to Memphis.

New 2025 itineraries feature a brand new 12-day Mississippi Explorer Cruise from Memphis to New Orleans, and several exclusive itineraries on the Tennessee, Cumberland and Ohio rivers.

These include a new 16-day Grand Ohio River Cruise from Pittsburgh to St. Louis.

Mississippi offerings also showcase two of the longest US river cruises on the market – the new 51-day Great United States and the 36-day Civil War Battlefields Cruise. 

Both sail the entire Mississippi or major sections of the river in addition to other US waterways.

American’s 2025 Mississippi river itineraries include:

Eight-day Historic Mississippi River Cruise round trip from New Orleans

Nine-day Lower Mississippi River Cruise from Memphis to New Orleans

Nine-day Upper Mississippi River Cruise from St. Louis to St. Paul

Nine-day Music Cities Cruise from Memphis to Nashville

Nine-day Tennessee Rivers Cruise from Nashville to Chattanooga

New: 12-day Mississippi Explorer Cruise from Memphis to New Orleans

12-day Mississippi River Gateway Cruise from New Orleans to Louisville

Nine-day Ohio River Cruise from Louisville to Pittsburgh

New: 16-day Grand Ohio River Cruise from Pittsburgh to St Louis

12-day Great Smoky Mountains National Park Cruise from Knoxville to Nashville

16-day Grand Heartland Cruise from St. Paul to New Orleans

23-day Complete Mississippi River Cruise from New Orleans to St. Paul

36-day Civil War Battlefields Cruise from New Orleans to Gettysburg

51-day Great United States Cruise from Portland to Boston

American is the only river cruise line offering US river cruises aboard both classic paddlewheelers and modern riverboats.

Highlights include visits to Elvis Presley’s Graceland and Mark Twain’s boyhood home; plus off-the-beaten track adventures from Cajun swamp safaris to ATV treks.

They explore classic American landmarks like the St. Louis Arch and Vicksburg National Military Park; as well as deep cultural dives into music, cuisine and history.

For UK cruisers, bookings can be made via Fred. Holidays, American Cruise Line’s preferred booking agent.

Prices for the 2025 Mississippi season start from £2,927 per person for the eight-day Historic Mississippi River Cruise round trip from New Orleans on 23 November 2025. It includes all meals and drinks, gratuities, port fees, onboard enrichment and entertainment, shore excursions and Wi-Fi.

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