British Airways will launch non-stop flights between London Heathrow and San Jose in summer 2016.
It will be the only airline offering daily flights between Europe and the key business airport.
Silicon Valley is home to hi-tech giants such as Adobe, Apple, Cisco, eBay, Google and Intel and thousands of tech start-up companies.
BA head of global sales Stephen Humphreys said: "We’re sure this new service will prove just the business for Californian-based companies looking to expand into Europe and will strengthen London’s strong commercial ties with the West Coast.
"It also offers a brilliant starting point for visitors to nearby Carmel and Monterey on the rugged central coast along highway one, and easy access to the unrivalled splendour of Yosemite National Park."
Fares will start from £599 return, during BA’s Big British Take Off.
Services start on May 4 and will be operated by the new 787-9 Dreamliner, which features BA’s very latest First cabin.
Return flights in First start from £3,675, from £2,900 in Club World, £899 in World Traveller Plus and £599 in World Traveller, including taxes and charges.
The BA 787-9 Dreamliner will make its first commercial flight from Heathrow to Delhi in October.
The aircraft will become the mainstay of BA’s long-haul fleet with 42 set to join the airline.
