Thomas Cook Airlines will operate a one-off flight from Cardiff to Cancun on its long haul Airbus A330 fleet next summer.
The flight, on May 24 2016, will offer 14-night holidays returning on June 7.
Last year, Thomas Cook Airlines announced flights from Cardiff to Orlando August 28 2015 and May 25 2016, again offering 14-night holidays.
Spencer Birns, aviation business development director at Cardiff Airport, said: "There is big demand for long haul flights and Mexico has always been a popular holiday destination as has Orlando."
