VLM Airlines will launch flights from Birmingham to Antwerp in October.
Starting on on October 5, the service will operate three times a week on Mondays, Wednesdays and Fridays, with one-way fares starting from £39.
The airline believes the route will be popular for business travel and for city breaks.
VLM Airlines now offers scheduled services to seven destinations in five countries, including Geneva, Hamburg, Southampton, Waterford and London Luton.
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