Iberia will launch flights from Madrid to Edinburgh and Manchester in 2015.
Flights to Edinburgh will start in March and will operate four times a week, rising to six in the high summer season.
Flights to Manchester will start in September, initially four a week.
In addition, the airline will strengthen its flights to London with twice-daily flights to Gatwick from March.
The three routes will be operated by Iberia Express.
Iberia currently flies up to eight times a day to Heathrow and offers another five daily flights on the same route under code-sharing with sister airline British Airways.
