Jet2and Jet2CityBreaks will introduce four one-off, four-night break to New York from London Stansted this winter.
The breaks, which will be operated by an Airbus A330, are now on sale.
There will be three shopping and winter breaks leaving Stansted on November 16, November 30 and December 7.
A special Thanksgiving and Black Friday break starts on November 23.
CEO Steve Heapy said: "We are delighted to be launching our popular New York trips from London Stansted Airport this year, making us the only airline and tour operator to fly directly to the Big Apple from the airport.
"With our flights and holidays programme performing exceptionally well from our new base, we expect the same level of popularity for these trips."
Hotels on offer include the budget Yotel New York at Times Square and Wellington Hotel, plus the Hilton Times Square, Sofitel New York and Loews Regency.
London Stansted CEO Andrew Cowan said: "The airport has not served the Big Apple since 2009 so we are all absolutely thrilled to have it back on our destination boards. I’m sure these great value flights will prove to be another huge hit with passengers."
Packages start from £699 per person while flight-only options are available from £299 per person, including taxes.
