Ryanair is ending its GDS partnership with Amadeus on December 15.
It said both parties were unable to reach a renewed commercial agreement.
Ryanair will continue to service travel agents through its GDS partnerships with Travelport and Sabre whose commercial agreements remain unchanged.
It had a partnership with Amadeus in place since September 2014.
Ryanair’s Kenny Jacobs said: "We wish Amadeus well and thank them for their support during our successful GDS partnership. We will continue to work together through our use of the Navitaire platform, an Amadeus company."
