MSC UK and Ireland sales director Stephen Moffett is leaving after eight years with the cruise line.
Moffett, who will leave in May, said it was time for him to move on.
"I have really enjoyed my time with MSC Cruises and am immensely proud of the growth we have achieved from the UK marketplace. I will be leaving the business in a strong position."
Giles Hawke, executive director of UK, Ireland and Australia, who joined the group in November, added: "Stephen has done a fantastic job in growing sales for MSC Cruises and he leaves the brand well positioned for its next growth phase.
"Maintaining and growing our excellent relationship with the trade is crucial for us and we are actively seeking a replacement for Stephen. I would like to thank him personally for his support and wish him well in his future career."
Moffett joined MSC from First Choice, where he was a sales manager.
