The 19th international half marathon will be held at World Heritage Site Angkor Wat temple complex on December 7.
During a press briefing Vath Chamroeun, secretary general of the National Olympic Committee of Cambodia said 4,000 professional and amateur runners from 65 countries had registered for the event so far.
The registration fee is US$45 for foreign athletes and US$5 for Cambodians and in addition to the half marathon 10km and 3km fun runs will take place.
Proceeds raised will be donated to the Cambodian Red Cross and support for land mine victims.
Last year’s race attracted over 7,500 runners.
"The event is vital to promote sports and tourism at the Angkor Wat temple," said Vath Chamroeun.
Angkor Wat is Cambodia’s premier tourist attraction and welcomed 1.74 million foreign visitors in the first nine months of 2014, up 11% on the same period last year.
