Worldspan is asking its 2,000 employees in the US to seek voluntary redundancy despite recording a profit of $105 million in the third quarter.
The global distribution system, owned by Delta, American and Northwest, does not release profit figures, but the details were included on an internal memo.
The company has not decided how many people will leave, but 100 employees left through a similar programme earlier in the year and another 100 were laid off.
A spokesman for Worldspan said the redundancies were needed because the economy was slow and there was extreme cost pressure on airlines.
Worldspan has around 3,000 employees worldwide.
