John Lewis is to open at Heathrow’s Terminal 2 on June 4 next year with home, fashion, gifts and seasonal ranges.
The retailer is investing more than £1 million on a top floor shop in the departure lounge.
It expects to create around 40 new jobs.
Andy Street, managing director, John Lewis said: "This new opening is a huge and exciting step forward in developing our international strategy, giving us access to one of the most concentrated, valuable and influential markets in the world.
"We recently made clear our ambition to further develop our online presence internationally in addition to increasing our international wholesale business. This opportunity at Heathrow perfectly complements and enhances these initiatives."
John Lewis delivers to 33 countries outside the UK and Ireland which equates to 75% of Terminal 2 destinations.
