Thomas Cook Airlines will launch direct flights to Cape Town next December.
The three times a week service from Gatwick will start on December 15 and run until March 20, 2017.
The flights, which will be the only ones to the South African city from the UK outside Heathrow, will operate on an Airbus A330.
The route will feature Thomas Cook’s new premium class cabin. Tickets will be priced from £699 return and will go on sale in December.
Christoph Debus, chief airlines and hotels officer for Thomas Cook, said: "Cape Town really is a ‘WOW!’ destination for our customers. It builds on our Cancun, Cuba and Goa long haul routes from Gatwick which are really popular and more broadly comes on top of new services from Manchester to New York and Miami this year, and to Los Angeles and Boston next year.
"Coupled with our premium class cabin and new long haul economy standard, our seat-only service, is proving hugely popular as customers become aware that they can get the great Thomas Cook quality to some amazing long haul destinations.
"With £100 million invested in our fleet and new cabin interiors, we’re flying more customers to better destinations on better aircraft and making long haul destinations accessible to everyone."
